Association of serum levels of anti-myeloperoxidase antibody with retinal photoreceptor ellipsoid zone disruption in diabetic retinopathy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F17%3A43876012" target="_blank" >RIV/62157124:16370/17:43876012 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.jdiacomp.2017.02.011" target="_blank" >http://dx.doi.org/10.1016/j.jdiacomp.2017.02.011</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jdiacomp.2017.02.011" target="_blank" >10.1016/j.jdiacomp.2017.02.011</a>

Result language

angličtina

Original language name

Association of serum levels of anti-myeloperoxidase antibody with retinal photoreceptor ellipsoid zone disruption in diabetic retinopathy

Original language description

Aim: To study the association of serum levels of anti-myeloperoxidase (MPO) antibody with retinal photoreceptor ellipsoid zone (EZ) disruption in diabetic retinopathy. Methods: Consecutive patients with type 2 DM [diabetes mellitus with no retinopathy (NODR; n = 20); non-proliferative diabetic retinopathy (NPDR; n = 18); proliferative diabetic retinopathy (PDR; n = 16)] and healthy controls (n = 20) between the ages of 40 and 65 years were included. Disruption of EZ was graded by spectral domain optical coherence tomography as no disruption of EZ and disrupted EZ The serum levels of anti-MPO antibody was analyzed using standard protocol. Association between the variables was evaluated using multiple regression analysis. Results: A significant difference was found between the serum levels of anti-MPO antibody in various study groups (p &lt; 0.001). A positive association was found between EZ disruption and levels of anti-MPO antibody [adjusted odd&apos;s ratio (AOR) = 1.079, CI 1.010-1124, p = 0.04]. A significant positive correlation was found between logMAR, visual acuity and grade of disruption (AOR = 1.008, CI 1.006-5.688, p = 0.04). Conclusions: An increased serum anti-MPO antibody levels is associated with retinal photoreceptor EZ disruption and decreased visual acuity in diabetic retinopathy.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30104 - Pharmacology and pharmacy

Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of diabetes and its complications

ISSN

1056-8727

e-ISSN

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Volume of the periodical

31

Issue of the periodical within the volume

5

Country of publishing house

US - UNITED STATES

Number of pages

5

Pages from-to

864-868

UT code for WoS article

000401683600015

EID of the result in the Scopus database

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