The Number of CAG Repeats Within the Normal Allele Does Not Influence the Age of Onset in Huntington's Disease

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A8930" target="_blank" >RIV/00216208:11110/11:8930 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/11:8930

Result on the web

<a href="http://dx.doi.org/10.1002/mds.23436" target="_blank" >http://dx.doi.org/10.1002/mds.23436</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The Number of CAG Repeats Within the Normal Allele Does Not Influence the Age of Onset in Huntington's Disease

Original language description

The purpose of this work was to examine the interaction between the normal and mutant alleles of this gene and their effect on the clinical onset of HD. Although the Cox regression coefficient of 0.15 was significant (P < 0.0001), the regression model explained only 28% of the variance of the age at onset related to the effect of the number of CAG repeats within normal allele. Within the groups of patients with the same number of CAG repeats of the mutant allele, number of CAG repeats of the normal allele was found uncorrelated to the age at onset. Furthermore, when analyzing subgroups of patients with the same allelic composition on both alleles, we failed to observe any correlation with the age at the onset.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Movement Disorders

ISSN

0885-3185

e-ISSN

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Volume of the periodical

26

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

5

Pages from-to

125-129

UT code for WoS article

000288178400023

EID of the result in the Scopus database

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