Human Galectins Induce Conversion of Dermal Fibroblasts into Myofibroblasts and Production of Extracellular Matrix: Potential Application in Tissue Engineering and Wound Repair
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A8933" target="_blank" >RIV/00216208:11110/11:8933 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/11:00368629 RIV/00216208:11130/11:7129 RIV/00064165:_____/11:8933
Result on the web
<a href="http://dx.doi.org/10.1159/000324864" target="_blank" >http://dx.doi.org/10.1159/000324864</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Human Galectins Induce Conversion of Dermal Fibroblasts into Myofibroblasts and Production of Extracellular Matrix: Potential Application in Tissue Engineering and Wound Repair
Original language description
We studied whether human galectins induce the conversion of human dermal fibroblasts into myofibroblasts and the production of a bioactive extracellular matrix scaffold.Testing a panel of galectins (natural and engineered variants), we detected activityfor the proto-type galectin-1 and galectin-7, the chimera-type galectin-3 and the tandemrepeat-type galectin-4. Their activity was independent of the presence of TGF-1, but it yielded an additive effect. The resulting myofibroblasts generated a matrix scaffold rich in fibronectin and galectin-1 that supported keratinocyte culture without feeder cells. In vivo in rats, galectin-1 had a positive effect on skin wound closure 21 days after surgery.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EI - Biotechnology and bionics
OECD FORD branch
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Result continuities
Project
<a href="/en/project/1M0538" target="_blank" >1M0538: Center for Cell Therapy and Tissue Repair</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cells, Tissues, Organs
ISSN
1422-6405
e-ISSN
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Volume of the periodical
194
Issue of the periodical within the volume
6
Country of publishing house
CH - SWITZERLAND
Number of pages
12
Pages from-to
469-480
UT code for WoS article
000297216700003
EID of the result in the Scopus database
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