Open Wound Healing In Vivo: Monitoring Binding and Presence of Adhesion/Growth-Regulatory Galectins in Rat Skin during the Course of Complete Re-Epithelialization.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A8942" target="_blank" >RIV/00216208:11110/11:8942 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1267/ahc.11014" target="_blank" >http://dx.doi.org/10.1267/ahc.11014</a>

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Open Wound Healing In Vivo: Monitoring Binding and Presence of Adhesion/Growth-Regulatory Galectins in Rat Skin during the Course of Complete Re-Epithelialization.

Original language description

Galectins are a family of carbohydrate-binding proteins that modulate inflammation and immunity. This functional versatility prompted us to perform a histochemical study of their occurrence during wound healing. In this study antibodies against keratins-10 and -14, wide-spectrum cytokeratin, vimentin, fibronectin, and galectins-1, -2, and -3 were applied to frozen sections of skin specimens two, seven, and twenty-one days after wounding. The presence of binding sites for galectins-1, -2, -3, and -7 wasdetermined using labeled proteins as probes. Our study detected a series of alterations in galectin parameters during different phases of wound healing. Presence of galectin-1 increased during the early phase of healing, whereas galectin-3 rapidly decreased in newly formed granulation tissue. In addition, nuclear reactivity of epidermal cells for galectin-2 occurred seven days post-trauma. The dynamic regulation of galectins during epithelization intimates a role of these proteins in wou

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FO - Dermatology and venereology

OECD FORD branch

—

Project

—

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Acta Histochemica et Cytochemica

ISSN

0044-5991

e-ISSN

—

Volume of the periodical

44

Issue of the periodical within the volume

5

Country of publishing house

JP - JAPAN

Number of pages

9

Pages from-to

191-199

UT code for WoS article

000298881100001

EID of the result in the Scopus database

—