Human galectin-3: Molecular switch of gene expression in dermal fibroblasts in vitro and of skin collagen organization in open wounds and tensile strength in incisions in vivo
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F21%3A00544840" target="_blank" >RIV/68378050:_____/21:00544840 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/21:43920839 RIV/00216208:11110/21:10419243
Result on the web
<a href="https://www.spandidos-publications.com/10.3892/mmr.2020.11738" target="_blank" >https://www.spandidos-publications.com/10.3892/mmr.2020.11738</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3892/mmr.2020.11738" target="_blank" >10.3892/mmr.2020.11738</a>
Alternative languages
Result language
angličtina
Original language name
Human galectin-3: Molecular switch of gene expression in dermal fibroblasts in vitro and of skin collagen organization in open wounds and tensile strength in incisions in vivo
Original language description
Understanding the molecular and cellular processes in skin wound healing can pave the way for devising innovative concepts by turning the identified natural effectors into therapeutic tools. Based on the concept of broad-scale engagement of members of the family of galactoside-binding lectins (galectins) in pathophysiological processes, such as cancer or tissue repair/regeneration, the present study investigated the potential of galectins-1 (Gal-1) and3 (Gal-3) in wound healing. Human dermal fibroblasts, which are key cells involved in skin wound healing, responded to galectin exposure (Gal-1 at 300 or Gal-3 at 600 ng/ml) with selective changes in gene expression among a panel of 84 wound-healing-related genes, as well as remodeling of the extracellular matrix. In the case of Gal-3, positive expression of Ki67 and cell number increased when using a decellularized matrix produced by Gal-3-treated fibroblasts as substrate for culture of interfollicular keratinocytes. In vivo wounds were topically treated with 20 ng/ml Gal-1 or3, and collagen score was found to be elevated in excisional wound repair in rats treated with Gal-3. The tensile strength measured in incisions was significantly increased from 79.5 +/- 17.5 g/mm(2) in controls to 103.1 +/- 21.4 g/mm(2) after 21 days of healing. These data warrant further testing mixtures of galectins and other types of compounds, for example a combination of galectins and TGF-beta 1.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecular Medicine Reports
ISSN
1791-2997
e-ISSN
1791-3004
Volume of the periodical
23
Issue of the periodical within the volume
2
Country of publishing house
GR - GREECE
Number of pages
11
Pages from-to
99
UT code for WoS article
000601339700001
EID of the result in the Scopus database
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