Toxocara canis larvae reinfecting BALB/c mice exhibit accelerated speed of migration to the host CNS

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A9006" target="_blank" >RIV/00216208:11110/11:9006 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11120/11:00003341 RIV/00064165:_____/11:9006 RIV/00023841:_____/11:#0000066

Result on the web

<a href="http://dx.doi.org/10.1007/s00436-011-2371-y" target="_blank" >http://dx.doi.org/10.1007/s00436-011-2371-y</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Toxocara canis larvae reinfecting BALB/c mice exhibit accelerated speed of migration to the host CNS

Original language description

Using a small animal imaging system, migratory activity of Toxocara canis larvae stained by carboxyfluorescein succinimidyl ester (CFSE) was observed post primary infection (PPI) and post reinfection (PR) of BALB/c mice. Each infection was performed with1,000 larvae per mouse. Primary infections were performed with labeled larvae, while for challenge infections the reinfecting larvae were stained by CFSE. The worm burden in mouse organs was determined during a period from 6 h to 21 days and 4 months PPI and PR. In comparison with primary infections that led to the first larvae appearance in the brain after 60 h, greatly accelerated migration of the parasites administered 3 weeks PPI to the CNS and eyes of challenged mice was noted-in both organs the larvae appeared 6 h PR. In all challenged mice, reinfecting larvae prevailed in the resident parasite population. Preliminary experiments with Toxocara cati larvae also revealed early brain involvement in primarily infected mice. Staining

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FN - Epidemiology, infection diseases and clinical immunology

OECD FORD branch

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Project

<a href="/en/project/GA310%2F08%2F1624" target="_blank" >GA310/08/1624: The study on Toxocara migration to the CNS in vivo</a><br>

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Parasitology Research

ISSN

0932-0113

e-ISSN

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Volume of the periodical

109

Issue of the periodical within the volume

5

Country of publishing house

DE - GERMANY

Number of pages

12

Pages from-to

1267-1278

UT code for WoS article

000296011300006

EID of the result in the Scopus database

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