Trichobilharzia regenti: Host immune response in the pathogenesis of neuroinfection in mice

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A9009" target="_blank" >RIV/00216208:11110/11:9009 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11310/11:10107925 RIV/00216208:11120/11:00003340 RIV/00023841:_____/11:#0000067

Result on the web

<a href="http://dx.doi.org/10.1016/j.exppara.2011.04.006" target="_blank" >http://dx.doi.org/10.1016/j.exppara.2011.04.006</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Trichobilharzia regenti: Host immune response in the pathogenesis of neuroinfection in mice

Original language description

Besides their natural bird hosts, Trichobilharzia regenti cercariae are able to penetrate skin of mammals, including humans. Experimental infections of mice showed that schistosomula of this species are able to avoid the immune response in skin of theirnon-specific mammalian host and escape the skin to migrate to the CNS. Schistosomula do not mature in mammals, but can survive in nervous tissue for several days post infection. Neuroinfections of specific bird hosts as well as accidental mammalian hostscan lead to neuromotor effects, for example, leg paralysis and thus this parasite serves as a model of parasite invasion of the CNS. Here, we show by histological and immunohistochemical investigation of CNS invasion of immunocompetent (BALB/c) and immunodeficient (SCID) mice by T. regenti schistosomula that the presence of parasites in the nervous tissue initiated an influx of immune cells, activation of microglia, astrocytes and development of inflammatory lesions. Schistosomula elimi

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FN - Epidemiology, infection diseases and clinical immunology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Experimental Parasitology

ISSN

0014-4894

e-ISSN

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Volume of the periodical

128

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

328-335

UT code for WoS article

000293670400005

EID of the result in the Scopus database

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