Impact of Induced Th1/Th2 Shift on Trichobilharzia regenti Infection in Mice

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F16%3A10327273" target="_blank" >RIV/00216208:11110/16:10327273 - isvavai.cz</a>

Result on the web

<a href="http://fb.cuni.cz/file/5799/fb2016a0003.pdf" target="_blank" >http://fb.cuni.cz/file/5799/fb2016a0003.pdf</a>

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Impact of Induced Th1/Th2 Shift on Trichobilharzia regenti Infection in Mice

Original language description

Bird schistosomes parasitize mammals as non-specific hosts. Neurotropic Trichobilharzia regenti migrates extravasally via nervous tissue in experimentally infected mice. The majority of successfully penetrated larvae remain in the skin; the rest migrate through peripheral nerves to the spinal cord and brain. The potential of schistosomula to leave the skin and enter the central nervous system vary, and may be associated with T(h)1/T(h)2 polarization of the host cell immune response. The aim of the present study was to evaluate the impact of induced shift in polarization of cell immune response on the migration of T. regenti larvae in mammals. For this purpose, non-specifically immunomodulated mice were infected. The localization and abundance of schistosomula and associated histopathological changes were followed using routine histological techniques. Markers characterizing T(h)1 and T(h)2 systemic immune responses were followed using flow cytometry. The study revealed that the shift towards T(h)1 response at the time of infection correlates with the speed and intensity of schistosomula migration towards the brain and with the severity of accompanying pathologies. This indicates increased health risks associated with T. regenti infection for mammals (potentially including human) with previously modulated cell immune response that may occur under natural conditions, e.g. due to the exposure to another infectious agent.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FN - Epidemiology, infection diseases and clinical immunology

OECD FORD branch

—

Project

<a href="/en/project/GPP302%2F12%2FP548" target="_blank" >GPP302/12/P548: Pathogenic impact of migrating larvae of bird schistosomes on mammalian host</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Folia Biologica

ISSN

0015-5500

e-ISSN

—

Volume of the periodical

62

Issue of the periodical within the volume

1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

8

Pages from-to

26-33

UT code for WoS article

000377711100003

EID of the result in the Scopus database

2-s2.0-84963974229