Cerebrospinal fluid IL-8 levels reflect symptoms of alexithymia in patients with non-inflammatory neurological disorders

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A9016" target="_blank" >RIV/00216208:11110/11:9016 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14740/11:00055565 RIV/00064165:_____/11:9016

Result on the web

<a href="http://dx.doi.org/10.1016/j.psyneuen.2011.02.006" target="_blank" >http://dx.doi.org/10.1016/j.psyneuen.2011.02.006</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Cerebrospinal fluid IL-8 levels reflect symptoms of alexithymia in patients with non-inflammatory neurological disorders

Original language description

Several recent findings indicate that various interactions between nervous and immune system are important in the pathophysiology of alexithymia. These findings show that a significant role in developing alexithymia may play proinflammatory cytokines. Recent data also indicate that negative emotions related to depressive symptoms and anxiety are related to disturbed levels of interleukin-8 (IL-8). These findings suggest that IL-8 could present also useful immunological marker related to emotional dysregulation in alexithymia. In the present study we have performed psychometric measurement of alexithymia (TAS-20), depression (BDI-II) and anxiety (SAS), and immunochemical measure of cerebrospinal fluid (CSF) and serum levels of IL-8 in 33 inpatients withnon-inflammatory neurological disorders (NIND) (mean age 38.8 +/- 12.5). The results show that IL-8 in CSF is significantly correlated with TAS-20 (Spearman R = 0.46, p = 0.007) and SAS (Spearman R = 0.44, p = 0.009) but not to BDI-II.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

<a href="/en/project/1M06039" target="_blank" >1M06039: Centre for neuropsychiatric research of the traumatic stress</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Psychoneuroendocrinology

ISSN

0306-4530

e-ISSN

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Volume of the periodical

36

Issue of the periodical within the volume

8

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

1148-1153

UT code for WoS article

000295072300005

EID of the result in the Scopus database

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