Cerebrospinal fluid S100B levels reflect symptoms of depression in patients with non-inflammatory neurological disorders

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A12053" target="_blank" >RIV/00216208:11110/12:12053 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/12:12053 RIV/00216224:14740/12:00072801
Result on the web
<a href="http://dx.doi.org/10.1016/j.neulet.2012.09.003" target="_blank" >http://dx.doi.org/10.1016/j.neulet.2012.09.003</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Cerebrospinal fluid S100B levels reflect symptoms of depression in patients with non-inflammatory neurological disorders
Original language description
Recent findings document numerous interactions between neuronal and glial systems that likely play a role in the pathophysiology of depression. These findings suggest that glia-derived neurotrophic protein S100B may play a significant role in developingdepression. To test the relationship between S100B and depressive symptoms we designed cross-sectional clinical study including S100B serum and CSF levels in neurological patients with non-inflammatory disorders (NIND), who undergone cerebrospinal fluidassessment for diagnostic purposes. The present study was focused on psychometric testing of depression (BDI-II). anxiety (SAS) and alexithymia (TAS-20), and neurochemical measure of cerebrospinal fluid (CSF) and serum levels of S100B in 40 NIND inpatients [mean age 41.67]. The main result shows that S100B in CSF is significantly negatively correlated with BDI-II (Spearman R=-0.51, p < 0.0009) but not with SAS and TAS-20. The finding indicates that decreased level of Si COB in CSF is rel
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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