Comprehensive Evaluation of One-Carbon Metabolism Pathway Gene Variants and Renal Cell Cancer Risk

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A9022" target="_blank" >RIV/00216208:11110/11:9022 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15110/11:10224490 RIV/00209805:_____/11:#0000174

Result on the web

<a href="http://dx.doi.org/10.1371/journal.pone.0026165" target="_blank" >http://dx.doi.org/10.1371/journal.pone.0026165</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Comprehensive Evaluation of One-Carbon Metabolism Pathway Gene Variants and Renal Cell Cancer Risk

Original language description

The strongest associations with renal cancer risk (RCC) risk were observed for SLC19A1 (P(min-P) = 0.03) and MTHFR (P(min-P) = 0.13). A haplotype consisting of four SNPs in SLC19A1 (rs12483553, rs2838950, rs2838951, and rs17004785) was associated with a37% increased risk (p = 0.02). Conclusions: To our knowledge, this is the first study to comprehensively examine those variation in relation to RCC risk. We identified a novel association with SLC19A1, which is important for transport of folate into cells. Replication in other populations is required to confirm these findings.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FM - Hygiene

OECD FORD branch

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Project

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Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

PLoS One

ISSN

1932-6203

e-ISSN

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Volume of the periodical

6

Issue of the periodical within the volume

10

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

"article"-"e26165"

UT code for WoS article

000296507500036

EID of the result in the Scopus database

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