Association of advanced vasculopathy and transforming growth factor-beta1 gene expression with immunoglobulin A nephropathy progression

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A9168" target="_blank" >RIV/00216208:11110/11:9168 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15110/11:10224652 RIV/00023001:_____/11:00002432 RIV/00064165:_____/11:9168
Result on the web
<a href="http://dx.doi.org/10.1093/ndt/gfq423" target="_blank" >http://dx.doi.org/10.1093/ndt/gfq423</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Association of advanced vasculopathy and transforming growth factor-beta1 gene expression with immunoglobulin A nephropathy progression
Original language description
Background. The mechanism of IgA nephropathy (IgAN) progression remains ill-defined. In this prospective study, the prognostic role of clinical, histological and molecular markers over a 2-year follow-up was evaluated. Methods. Fifty-one patients with biopsy-proven IgAN were followed for 24 months. Besides routine histology, the intrarenal gene expressions of cytokines and chemokines were quantified by reverse transcription quantitative real-time polymerase chain reaction, and the presence of lymphocytes and macrophages were immunohistochemically examined. Results. Higher transforming growth factor-beta 1 and severe chronic vasculopathy (but not glomerulosclerosis, interstitial fibrosis or lymphocyte infiltrate) were associated with the IgAN progression 24 months after biopsy. The gene expression of chemokine (C-C motif) ligands 2 and 5, hepatocyte growth factor, bone morphogenic protein-7 and transforming growth factor-beta 1 and the interstitial infiltrate of Tand B lymphocytes and m
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FE - Other fields of internal medicine
OECD FORD branch
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Project
<a href="/en/project/NR8913" target="_blank" >NR8913: The expression of proinflammatory genes in patients with IgA nephropathy and their relation to the disease outcome</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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