The level of serum visfatin (PBEF) is associated with total number of B cells in patients with rheumatoid arthritis and decreases following B cell depletion therapy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A9584" target="_blank" >RIV/00216208:11110/11:9584 - isvavai.cz</a>

Alternative codes found

RIV/00023728:_____/11:#0001050 RIV/00064165:_____/11:9584

Result on the web

<a href="http://dx.doi.org/10.1016/j.cyto.2011.04.004" target="_blank" >http://dx.doi.org/10.1016/j.cyto.2011.04.004</a>

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

The level of serum visfatin (PBEF) is associated with total number of B cells in patients with rheumatoid arthritis and decreases following B cell depletion therapy

Original language description

Objective: Visfatin, also known as pre-B cell colony-enhancing factor, was recently characterized as a potent pro-inflammatory mediator in rheumatoid arthritis (RA). The aim of this study was to determine the effect of B cell depletion with rituximab onserum visfatin levels in patients with active RA. Methods: We evaluated 31 patients with RA starting rituximab therapy at baseline and after 16 and 24 weeks using disease activity score (DAS28). The control group consisted of 33 gender and age-matched healthy individuals. CD19(+) B cells were assessed by flow cytometry and serum levels of visfatin and B cell-activating factor of the TNF family (BAFF) were measured by ELISA at baseline and week 16. Results: Total number of B cells correlated positively with serum visfatin levels (rs = 0.417, P = 0.025) and negatively with serum BAFF levels (rs = -0.486, P = 0.008) at baseline. Serum visfatin levels were significantly higher in patients with RA compared with healthy controls (P = 0.026),

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EC - Immunology

OECD FORD branch

—

Project

<a href="/en/project/NS10614" target="_blank" >NS10614: Predictive value of adipokines in rheuamtoid arthritis</a><br>

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cytokine

ISSN

1043-4666

e-ISSN

—

Volume of the periodical

55

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

116-121

UT code for WoS article

000291916300018

EID of the result in the Scopus database

—