Increase of intracellular BAFF in B cells of Sjögren's patients is not affected by decrease of BAFFR

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F15%3A10295372" target="_blank" >RIV/00216208:11150/15:10295372 - isvavai.cz</a>

Alternative codes found

RIV/00179906:_____/15:10295372

Result on the web

<a href="http://actamedica.lfhk.cuni.cz/media/pdf/am_2015058010025.pdf" target="_blank" >http://actamedica.lfhk.cuni.cz/media/pdf/am_2015058010025.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14712/18059694.2015.88" target="_blank" >10.14712/18059694.2015.88</a>

Result language

angličtina

Original language name

Increase of intracellular BAFF in B cells of Sjögren's patients is not affected by decrease of BAFFR

Original language description

The presence of a broad spectrum of autoantibodies in Sjögren's syndrome (SjS) patients in the result of abnormal B-cell regulation that can be at least partially explained by abnormal BAFF/BAFFR regulation. The objective of this study was to determine both membrane and intracellular expression of BAFF/BAFFR in monocytes and B-cells in peripheral blood of 19 primary Sjögren's syndrome patients and 20 healthy controls using flow cytometry. We also measured sBAFF in serum. Compared to healthy controls, both surface and intracellular expression of BAFF was significantly increased in monocytes and B-cells of SjS patients. Also serum sBAFF level was elevated. Expression of BAFFR on B-cells of SjS patients was surprisingly decreased, but there was no clear increase or decrease within monocytes. Our results indicate that activated monocytes communicate with B-cells via BAFF and BAFFR, so that B-cells are stimulated, but BAFF is also produced to stimulate cells in autocrine way. The decrease o

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FN - Epidemiology, infection diseases and clinical immunology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Acta Medica (Hradec Králové)

ISSN

1211-4286

e-ISSN

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Volume of the periodical

58

Issue of the periodical within the volume

1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

7

Pages from-to

25-31

UT code for WoS article

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EID of the result in the Scopus database

2-s2.0-84953410710