Low marginal zone-like B lymphocytes and natural antibodies characterize skewed B-lymphocyte subpopulations in del22q11 DiGeorge patients
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F15%3A10315341" target="_blank" >RIV/00216208:11130/15:10315341 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/15:10315341
Result on the web
<a href="http://dx.doi.org/10.1016/j.clim.2015.08.013" target="_blank" >http://dx.doi.org/10.1016/j.clim.2015.08.013</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.clim.2015.08.013" target="_blank" >10.1016/j.clim.2015.08.013</a>
Alternative languages
Result language
angličtina
Original language name
Low marginal zone-like B lymphocytes and natural antibodies characterize skewed B-lymphocyte subpopulations in del22q11 DiGeorge patients
Original language description
Purpose: Patients with DiGeorge syndrome suffer from T-Iymphopenia.T-cells are important for the maturation and regulation of B-cell function. Our aim was to characterize the B-cell compartment in DiGeorge syndrome patients. Methods: B-cell subset phenotypization using flow cytometry. Serum BAFF (B-cell activating factor) and serum anti-alpha-galactosyl IgM measurement using ELISA. Serum IgG measurement using nephelometry. Results: We observed a significantly increased number of naive B-cells and decreased number of switched memory B-cells in DiGeorge patients. Furthermore, we observed increased BAFF levels and a trend toward hypergammaglobulinemia later in life. Surprisingly, we detected a decrease in marginal zone-like (MZ-like) Bcells and natural antibodies in DiGeorge patients. Conclusion: The maturation of B-cells is impaired in DiGeorge patients, with high naive and low switched memory B-cell numbers being observed. There is a clear trend toward hypergammaglobulinemia later in li
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NT13287" target="_blank" >NT13287: The regulation of immunity in syndrome diGeorge</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical Immunology
ISSN
1521-6616
e-ISSN
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Volume of the periodical
161
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
144-149
UT code for WoS article
000365831600012
EID of the result in the Scopus database
2-s2.0-84942517704