Dual effect of lobeline on alpha 4 beta 2 rat neuronal nicotinic receptors

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A9730" target="_blank" >RIV/00216208:11110/11:9730 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/11:00372065 RIV/00216208:11310/11:10110522 RIV/00064203:_____/11:7486
Result on the web
<a href="http://dx.doi.org/10.1016/j.ejphar.2011.02.012" target="_blank" >http://dx.doi.org/10.1016/j.ejphar.2011.02.012</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Dual effect of lobeline on alpha 4 beta 2 rat neuronal nicotinic receptors
Original language description
The effect of lobeline on rat alpha 4 beta 2 nicotinic receptors expressed in COS cells was studied using the patch-clamp technique. Currents were recorded in whole-cell mode 2-4 days after cell transfection by plasmids coding the alpha 4 beta 2 combination of receptor subunits. In cells sensitive to acetylcholine, the application of lobeline evoked minor responses (up to 2% of maximal acetylcholine response). When acetylcholine was applied to the background of an already running application of lobeline, acetylcholine responses were inhibited in a concentration- and time dependent manner. However, when lobeline was applied simultaneously with acetylcholine without any prepulse or during an already running application of acetylcholine, the acetylcholineresponses were potentiated up to 300-600% of that of the control. The site of lobeline action overlaps with the cholinergic site, as was proven by the partially protective effect of (+)-tubocurarine. Thus, lobeline can apparently desensi
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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