Different effects of lobeline on neuronal and muscle nicotinic receptors
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10285285" target="_blank" >RIV/00216208:11310/14:10285285 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/14:00437656 RIV/00216208:11110/14:10285285 RIV/00064203:_____/14:10285285
Result on the web
<a href="http://dx.doi.org/10.1016/j.ejphar.2014.05.057" target="_blank" >http://dx.doi.org/10.1016/j.ejphar.2014.05.057</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ejphar.2014.05.057" target="_blank" >10.1016/j.ejphar.2014.05.057</a>
Alternative languages
Result language
angličtina
Original language name
Different effects of lobeline on neuronal and muscle nicotinic receptors
Original language description
Lobeline is a plant alkaloid known to interact with cholinergic system. The effect of lobeline on neuronal alpha 3 beta 4 receptors expressed in COS cells and muscle embryonic alpha beta gamma delta receptors naturally expressed in TE671 cells was studied using a patch clamp technique. Our results show that lobeline inhibited responses to acetylcholine in human embryonic muscle nicotinic receptor in a pseudo noncompetitive manner. The responses of rat neuronal alpha 3 beta 4 receptors to a low concentration of acetylcholine were potentiated by a mixed occupation mechanism that corresponds to "competitive potentiation". This potentiation turned into voltage dependent inhibition for alpha 3 beta 4 receptors was activated by a high concentration of acetylcholine.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Pharmacology
ISSN
0014-2999
e-ISSN
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Volume of the periodical
738
Issue of the periodical within the volume
June
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
8
Pages from-to
352-359
UT code for WoS article
000339998000044
EID of the result in the Scopus database
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