Differential Expression of MicroRNAs in CD34+ Cells of 5q- Syndrome

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A9743" target="_blank" >RIV/00216208:11110/11:9743 - isvavai.cz</a>
Alternative codes found
RIV/00023736:_____/11:00009168 RIV/00064165:_____/11:9743
Result on the web
<a href="http://dx.doi.org/10.1186/1756-8722-4-1" target="_blank" >http://dx.doi.org/10.1186/1756-8722-4-1</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Differential Expression of MicroRNAs in CD34+ Cells of 5q- Syndrome
Original language description
MicroRNAs (miRNAs) are important regulators of hematopoiesis and their aberrant expression was detected in some clonal hematopoietic disorders. We thus analyzed miRNA expressions in bone marrow CD34+ cells of 5q- syndrome patients. within the 5q deletion. Using microarrays we identified 21 differently expressed miRNAs in 5q- patients compared to controls. Especially, miR-34a was markedly overexpressed in 5q- patients, suggesting its role in an increased apoptosis of bone marrow progenitors.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
<a href="/en/project/GP301%2F09%2FP579" target="_blank" >GP301/09/P579: Importance of miRNA deregulation in myelodysplastic syndromes and in other hematological clonal diseases</a><br>
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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