Early Diagnosis of Pancreatic Adenocarcinoma Role of Stroma, Surface Proteases, and Glucose-Homeostatic Agents
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A11420" target="_blank" >RIV/00216208:11110/12:11420 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1097/MPA.0b013e31823b5827" target="_blank" >http://dx.doi.org/10.1097/MPA.0b013e31823b5827</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Early Diagnosis of Pancreatic Adenocarcinoma Role of Stroma, Surface Proteases, and Glucose-Homeostatic Agents
Original language description
Objectives: New-onset diabetes in pancreatic adenocarcinoma is due to a combination of insulin resistance and decreased A-cell function. Its differentiation from the common type 2 diabetes is the prerequisite for early diagnosis of pancreatic adenocarcinoma. Little attention has been paid to pancreatic stroma and surface proteases. Methods: The activated fibroblasts selectively express fibroblast activation protein alpha , a structural homolog of the ubiquitously expressed dipeptidyl peptidase 4. Theirrole in pancreatic carcinogenesis is reviewed. Results: Homodimers and heterodimers of both enzymes display high specificity for peptides and proteins with penultimate proline or alanine. Most glucose-homeostatic agents are candidate substrates of theseenzymes. The biological activity of truncated substrates is decreased or absent. Conclusions: The interactions of surface proteases with glucose-homeostatic agents may adequately explain the evolution of diabetes associated with pancreati
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FE - Other fields of internal medicine
OECD FORD branch
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Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pancreas
ISSN
0885-3177
e-ISSN
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Volume of the periodical
41
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
663-670
UT code for WoS article
000306061900001
EID of the result in the Scopus database
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