The Effect of Neural Noise on Spike Time Precision in a Detailed CA3 Neuron Model
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A11450" target="_blank" >RIV/00216208:11110/12:11450 - isvavai.cz</a>
Alternative codes found
RIV/68407700:21460/12:00201975
Result on the web
<a href="http://dx.doi.org/10.1155/2012/595398" target="_blank" >http://dx.doi.org/10.1155/2012/595398</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
The Effect of Neural Noise on Spike Time Precision in a Detailed CA3 Neuron Model
Original language description
Experimental and computational studies emphasize the role of the millisecond precision of neuronal spike times as an important coding mechanism for transmitting and representing information in the central nervous system. We investigate the spike time precision of a multicompartmental pyramidal neuron model of the CA3 region of the hippocampus under the influence of various sources of neuronal noise. We describe differences in the contribution to noise originating from voltage-gated ion channels, synaptic vesicle release, and vesicle quantal size. We analyze the effect of interspike intervals and the voltage course preceding the firing of spikes on the spike-timing jitter. The main finding of this study is the ranking of different noise sources according to their contribution to spike time precision. The most influential is synaptic vesicle release noise, causing the spike jitter to vary from 1ms to 7 ms of a mean value 2.5 ms. Of second importance was the noise incurred by vesicle quan
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Computational and mathematical methods in medicine
ISSN
1748-670X
e-ISSN
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Volume of the periodical
Neuveden
Issue of the periodical within the volume
Article Number: 595398
Country of publishing house
GB - UNITED KINGDOM
Number of pages
16
Pages from-to
1-16
UT code for WoS article
000307564100001
EID of the result in the Scopus database
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