Regular spiking in high-conductance states: The essential role of inhibition

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F21%3A00541638" target="_blank" >RIV/67985823:_____/21:00541638 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/21:10427399
Result on the web
<a href="https://doi.org/10.1103/PhysRevE.103.022408" target="_blank" >https://doi.org/10.1103/PhysRevE.103.022408</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1103/PhysRevE.103.022408" target="_blank" >10.1103/PhysRevE.103.022408</a>

Result language
angličtina
Original language name
Regular spiking in high-conductance states: The essential role of inhibition
Original language description
Strong inhibitory input to neurons, which occurs in balanced states of neural networks, increases synaptic current fluctuations. This has led to the assumption that inhibition contributes to the high spike-firing irregularity observed in vivo. We used single compartment neuronal models with time-correlated (due to synaptic filtering) and state-dependent (due to reversal potentials) input to demonstrate that inhibitory input acts to decrease membrane potential fluctuations, a result that cannot be achieved with simplified neural input models. To clarify the effects on spike-firing regularity, we used models with different spike-firing adaptation mechanisms, and we observed that the addition of inhibition increased firing regularity in models with dynamic firing thresholds and decreased firing regularity if spike-firing adaptation was implemented through ionic currents or not at all. This fluctuation-stabilization mechanism provides an alternative perspective on the importance of strong inhibitory inputs observed in balanced states of neural networks, and it highlights the key roles of biologically plausible inputs and specific adaptation mechanisms in neuronal modeling.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10602 - Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology

Project
<a href="/en/project/GA20-10251S" target="_blank" >GA20-10251S: Optimality of neuronal communication: an information-theoretic perspective</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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