Alteration of the Circadian Clock in Children with Smith-Magenis Syndrome

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A11578" target="_blank" >RIV/00216208:11110/12:11578 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/12:00376807 RIV/00064165:_____/12:11578
Result on the web
<a href="http://dx.doi.org/10.1210/jc.2011-2750" target="_blank" >http://dx.doi.org/10.1210/jc.2011-2750</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Alteration of the Circadian Clock in Children with Smith-Magenis Syndrome
Original language description
Context: Smith-Magenis syndrome (SMS) is associated with sleep disturbances and disrupted melatonin production. Objectives: The study aimed to ascertain whether the sleep and melatonin production anomalies in SMS patients may be due to an alteration of the molecular mechanism of the circadian clock. Subjects and Methods: Five SMS patients (3-17 yr old) and five healthy age-matched control subjects were involved in the study. Saliva and buccal scrub samples were collected every 4 h during a 24-h period.Daily profiles of melatonin were determined in saliva using a direct double-antibody radioimmunoassay. Daily profiles of clock gene mRNA levels (Per1, Per2, and Rev-erb alpha) were determined in buccal scrub samples by RT-PCR. Results: In controls, melatonin levels were elevated during the nighttime and very low during the daytime. Daily profiles of clock genes, Per1, Per2, and Rev-erb alpha, mRNA levels in buccal mucosa exhibited significant and mutually synchronized circadian variation
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
<a href="/en/project/NT11474" target="_blank" >NT11474: Determination of functional state of the human circadian system and its changes in depression and bipolar disorder</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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