Genome-Wide Association Study of Classical Hodgkin Lymphoma and Epstein-Barr Virus Status-Defined Subgroups
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A11677" target="_blank" >RIV/00216208:11110/12:11677 - isvavai.cz</a>
Alternative codes found
RIV/00209805:_____/12:#0000355
Result on the web
<a href="http://dx.doi.org/10.1093/jnci/djr516" target="_blank" >http://dx.doi.org/10.1093/jnci/djr516</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Genome-Wide Association Study of Classical Hodgkin Lymphoma and Epstein-Barr Virus Status-Defined Subgroups
Original language description
Accumulating evidence suggests that risk factors for classical Hodgkin lymphoma (cHL) differ by tumor Epstein-Barr virus (EBV) status. This potential etiological heterogeneity is not recognized in current disease classification. We conducted a genome-wide association study of 1200 cHL patients and 6417 control subjects, with validation in an independent replication series, to identify common genetic variants associated with total cHL and subtypes defined by tumor EBV status. Multiple logistic regressionwas used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) assuming a log-additive genetic model for the variants. All statistical tests were two-sided. Two novel loci associated with total cHL irrespective of EBV status were identifiedin the major histocompatibility complex region; one resides adjacent to MICB and the other at HLA-DRA with both results confirmed in an independent replication series. Consistent with previous reports, associations were found between EBV-
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of the national cancer institute
ISSN
0027-8874
e-ISSN
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Volume of the periodical
104
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
14
Pages from-to
240-253
UT code for WoS article
000300343000012
EID of the result in the Scopus database
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