Impact of Tumour Epstein–Barr Virus Status on ClinicalOutcome in Patients with Classical Hodgkin Lymphoma (cHL):A Review of the Literature and Analysis of a Clinical TrialCohort of Children with cHL

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F22%3A73617245" target="_blank" >RIV/61989592:15110/22:73617245 - isvavai.cz</a>

Result on the web

<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454639/pdf/cancers-14-04297.pdf" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454639/pdf/cancers-14-04297.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/cancers14174297" target="_blank" >10.3390/cancers14174297</a>

Result language

angličtina

Original language name

Impact of Tumour Epstein–Barr Virus Status on ClinicalOutcome in Patients with Classical Hodgkin Lymphoma (cHL):A Review of the Literature and Analysis of a Clinical TrialCohort of Children with cHL

Original language description

In this study, we have re-evaluated how EBV status influences clinical outcome. Toaccomplish this, we performed a literature review of all studies that have reported the effect of EBVstatus on patient outcome and also explored the effect of EBV positivity on outcome in a clinical trialof children with cHL from the UK. Our literature review revealed that almost all studies of olderadults/elderly patients have reported an adverse effect of an EBV-positive status on outcome. Inyounger adults with cHL, EBV-positive status was either associated with a moderate beneficial effector no effect, and the results in children and adolescents were conflicting. Our own analysis of a seriesof 166 children with cHL revealed no difference in overall survival between EBV-positive and EBV-negative groups (p= 0.942, log rank test). However, EBV-positive subjects had significantly longerevent-free survival (p= 0.0026). Positive latent membrane protein 1 (LMP1) status was associatedwith a significantly lower risk of treatment failure in a Cox regression model (HR = 0.21,p= 0.005). Inmodels that controlled for age, gender, and stage, EBV status had a similar effect size and statisticalsignificance. This study highlights the age-related impact of EBV status on outcome in cHL patientsand suggests different pathogenic effects of EBV at different stages of life

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30204 - Oncology

Project

<a href="/en/project/EF16_019%2F0000868" target="_blank" >EF16_019/0000868: Molecular, cellular and clinical approach to healthy ageing</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cancers

ISSN

2072-6694

e-ISSN

—

Volume of the periodical

14

Issue of the periodical within the volume

17

Country of publishing house

CH - SWITZERLAND

Number of pages

15

Pages from-to

4297

UT code for WoS article

000851059200001

EID of the result in the Scopus database

2-s2.0-85137767728