Low serum deoxyribonuclease I activity is associated with antiTNF-alpha induced skin adverse events in patients with inflammatory bowel disease

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A11759" target="_blank" >RIV/00216208:11110/12:11759 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/12:11759

Result on the web

<a href="http://www.csgh.info/dwnld/gh_2012_1_23_31.pdf" target="_blank" >http://www.csgh.info/dwnld/gh_2012_1_23_31.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Low serum deoxyribonuclease I activity is associated with antiTNF-alpha induced skin adverse events in patients with inflammatory bowel disease

Original language description

A significant proportion of inflammatory bowel disease (IBD) patients develop skin complications during infliximab or adalimumab therapy. Both drugs are thought to act via induction of apoptosis in activated inflammatory cells.Deoxyribonuclease (DNase) Iis endonuclease hydrolyzing double-stranded DNA during apoptosis and its deficiency has been implicated in several autoimmune disorders.Low DNase I activity may be a risk factor for development of immune-mediated skin complications during biological therapy in patients with IBD.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EC - Immunology

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Gastroenterologie a hepatologie

ISSN

1804-7874

e-ISSN

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Volume of the periodical

66

Issue of the periodical within the volume

1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

9

Pages from-to

23-31

UT code for WoS article

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EID of the result in the Scopus database

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