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Low serum deoxyribonuclease I activity is associated with antiTNF-alpha induced skin adverse events in patients with inflammatory bowel disease

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A11759" target="_blank" >RIV/00216208:11110/12:11759 - isvavai.cz</a>

  • Alternative codes found

    RIV/00064165:_____/12:11759

  • Result on the web

    <a href="http://www.csgh.info/dwnld/gh_2012_1_23_31.pdf" target="_blank" >http://www.csgh.info/dwnld/gh_2012_1_23_31.pdf</a>

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Low serum deoxyribonuclease I activity is associated with antiTNF-alpha induced skin adverse events in patients with inflammatory bowel disease

  • Original language description

    A significant proportion of inflammatory bowel disease (IBD) patients develop skin complications during infliximab or adalimumab therapy. Both drugs are thought to act via induction of apoptosis in activated inflammatory cells.Deoxyribonuclease (DNase) Iis endonuclease hydrolyzing double-stranded DNA during apoptosis and its deficiency has been implicated in several autoimmune disorders.Low DNase I activity may be a risk factor for development of immune-mediated skin complications during biological therapy in patients with IBD.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EC - Immunology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2012

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Gastroenterologie a hepatologie

  • ISSN

    1804-7874

  • e-ISSN

  • Volume of the periodical

    66

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    9

  • Pages from-to

    23-31

  • UT code for WoS article

  • EID of the result in the Scopus database