Leukotrienes B4, C4, D4 and E4 in the Exhaled Breath Condensate (EBC), Blood and Urine in Patients with Pneumoconiosis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A11952" target="_blank" >RIV/00216208:11110/12:11952 - isvavai.cz</a>

Alternative codes found

RIV/61388971:_____/12:00379903 RIV/61388955:_____/12:00379903 RIV/60461373:22310/12:43894599 RIV/60461373:22340/12:43894599 RIV/00064165:_____/12:11952

Result on the web

<a href="https://www.jstage.jst.go.jp/article/indhealth/50/4/50_MS1274/_pdf" target="_blank" >https://www.jstage.jst.go.jp/article/indhealth/50/4/50_MS1274/_pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Leukotrienes B4, C4, D4 and E4 in the Exhaled Breath Condensate (EBC), Blood and Urine in Patients with Pneumoconiosis

Original language description

Leukotrienes (LTs) are involved in the pathogenesis of lung fibrosis and were increased in exhaled breath condensate (EBC) of the patients with pneumoconiosis. However the possible influence of extra-pulmonary disorders on the EBC markers is not known. Therefore in parallel with EBC, LTs' levels in the plasma and urine were measured in patients with pneumoconiosis (45 x asbestos exposure, 37 x silica exposure) and in 27 controls. Individual LTs B4, C4, D4 and E4 were measured by liquid chromatography -electrospray ionization - tandem mass spectrometry (LC-ESI-MS/MS). In EBC, LT 04 and LT E4 were increased in both groups of patients (p<0.001 and p<0.05), comparing with the controls. Both LT B4 and cysteinyl LTs were elevated in asbestos-exposed subjects (p<0.05). Asbestosis with more severe radiological signs (s1/s2 t3/u2) and lung functions impairment has shown higher cysteinyl LTs and LT C4 in the EBC (p<0.05) than mild asbestosis (s1/s0 s1/s1). In addition, in the subjects with asbe

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FE - Other fields of internal medicine

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Industrial Health

ISSN

0019-8366

e-ISSN

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Volume of the periodical

50

Issue of the periodical within the volume

4

Country of publishing house

JP - JAPAN

Number of pages

8

Pages from-to

299-306

UT code for WoS article

000307133500007

EID of the result in the Scopus database

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