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Effect of a Selective Progesterone Receptor Modulator on Induction of Apoptosis in Uterine Fibroids In Vivo

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A12447" target="_blank" >RIV/00216208:11110/12:12447 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11130/12:8195 RIV/65269705:_____/12:#0001803 RIV/00064203:_____/12:8195 RIV/00064165:_____/12:12447

  • Result on the web

    <a href="http://dx.doi.org/10.1155/2012/436174" target="_blank" >http://dx.doi.org/10.1155/2012/436174</a>

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Effect of a Selective Progesterone Receptor Modulator on Induction of Apoptosis in Uterine Fibroids In Vivo

  • Original language description

    Aim. To determine if hormonal treatment induces apoptosis in uterine fibroids. Methods. Immunohistochemical examination of fibroid tissue, using avidin-biotin complex and cleaved caspase-3 antibody for detecting apoptosis, was performed in premenopausalwomen who underwent 12-week treatment with oral SPRM (6 patients with 5 mg and 5 patients with 10 mg of ulipristal acetate per day) or gonadoliberin agonist (GnRHa, 17 patients) and subsequent myomectomy or hysterectomy for symptomatic uterine fibroids.Ten patients with no presurgical hormonal treatment were used as controls. Results. Apoptosis was present in a significantly higher proportion of patients treated with ulipristal acetate compared to GnRHa (P = 0.01) and to patients with no hormonal treatment (P = 0.01). In contrast to an AI of 158.9 in SPRM patients, the mean AI was 27.5 and 2.0 in GnRHa and control groups, respectively. No statistical difference in the AI was observed between the two groups of patients treated with ulip

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FK - Gynaecology and obstetrics

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/NS9798" target="_blank" >NS9798: The occlusive methods of treatment of uterine fibroids in women of fertile age</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2012

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    International Journal of Endocrinology

  • ISSN

    1687-8337

  • e-ISSN

  • Volume of the periodical

    Neuveden

  • Issue of the periodical within the volume

    Article Number: 436174

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    6

  • Pages from-to

    1-6

  • UT code for WoS article

    000307706900001

  • EID of the result in the Scopus database