Efficacy and safety of repeated use of ulipristal acetate in uterine fibroids

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F15%3A00082298" target="_blank" >RIV/00216224:14110/15:00082298 - isvavai.cz</a>
Alternative codes found
RIV/65269705:_____/15:00062983
Result on the web
<a href="http://dx.doi.org/10.1016/j.fertnstert.2014.10.038" target="_blank" >http://dx.doi.org/10.1016/j.fertnstert.2014.10.038</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.fertnstert.2014.10.038" target="_blank" >10.1016/j.fertnstert.2014.10.038</a>

Result language
angličtina
Original language name
Efficacy and safety of repeated use of ulipristal acetate in uterine fibroids
Original language description
Objective: To investigate the efficacy and safety of repeated 12-week courses of 5 or 10 mg daily of ulipristal acetate for intermittent treatment of symptomatic uterine fibroids. Design: Double-blind, randomized administration of two 12-week courses ofulipristal acetate. Setting: Gynecology centers. Patient(s): A total of 451 patients with symptomatic uterine fibroid(s) and heavy bleeding. Intervention(s): Two repeated 12-week treatment courses of daily 5 or 10 mg of ulipristal acetate. Main Outcome Measure(s): Amenorrhea, controlled bleeding, fibroid volume, quality of life (QoL), pain. Result(s): In the 5- and 10-mg treatment groups (62% and 73% of patients, respectively) achieved amenorrhea during both treatment courses. Proportions of patients achieving controlled bleeding during two treatment courses were >80%. Menstruation resumed after each treatment course and was diminished compared with baseline.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FK - Gynaecology and obstetrics
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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