Pressure Overload Selectively Increases n-3 PUFA in Myocardial Phospholipids During Early Postnatal Period

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A12535" target="_blank" >RIV/00216208:11110/12:12535 - isvavai.cz</a>

Alternative codes found

RIV/67985823:_____/12:00381020 RIV/00216208:11310/12:10130397

Result on the web

<a href="http://www.biomed.cas.cz/physiolres/pdf/61%20Suppl%201/61_S155.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/61%20Suppl%201/61_S155.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Pressure Overload Selectively Increases n-3 PUFA in Myocardial Phospholipids During Early Postnatal Period

Original language description

Increasing hemodynamic load during early postnatal development leads to rapid growth of the left ventricular (LV) myocardium, which is associated with membrane phospholipid (PL) remodeling characterized by n-3 polyunsaturated fatty acids (PUFA) accumulation. The aim of this study was to examine the influence of additional workload imposed early after birth when ventricular myocytes are still able to proliferate. Male Wistar rats were subjected to abdominal aortic constriction (AC) at postnatal day 2. Concentrations of PL and their fatty acid (FA) profiles in the LV were analyzed in AC, sham-operated (SO) and intact animals on postnatal days 2 (intact only), 5 and 10. AC resulted in LV enlargement by 22 % and 67 % at days 5 and 10, respectively, compared with age-matched SO littermates. Concentrations of phosphatidylcholine, cardiolipin, phosphatidylinositol, phosphatidylethanolamine, phosphatidylserine and sph ngomyelin decreased in AC myocardium, albeit with different time course and

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

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Volume of the periodical

61

Issue of the periodical within the volume

Suppl.1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

9

Pages from-to

"S155"-"S163"

UT code for WoS article

000307133700012

EID of the result in the Scopus database

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