Hedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A12639" target="_blank" >RIV/00216208:11110/12:12639 - isvavai.cz</a>

Result on the web

<a href="http://onlinelibrary.wiley.com/doi/10.1002/art.34444/abstract;jsessionid=DF320B203BD50E01634E07F9FA6D183A.d03t02" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/art.34444/abstract;jsessionid=DF320B203BD50E01634E07F9FA6D183A.d03t02</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Hedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis

Original language description

We demonstrated that the hedgehog pathway is activated in patients with SSc. Hedgehog signaling potently stimulates the release of collagen and myofibroblast differentiation in vitro and is sufficient to induce fibrosis in vivo. These findings identify the hedgehog cascade as a profibrotic pathway in SSc.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FE - Other fields of internal medicine

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Arthritis & Rheumatism

ISSN

0004-3591

e-ISSN

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Volume of the periodical

64

Issue of the periodical within the volume

8

Country of publishing house

US - UNITED STATES

Number of pages

10

Pages from-to

2724-2733

UT code for WoS article

000306906500033

EID of the result in the Scopus database

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