Inhibition of hedgehog signaling for the treatment of murine sclerodermatous chronic graft-versus-host disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A12687" target="_blank" >RIV/00216208:11110/12:12687 - isvavai.cz</a>
Alternative codes found
RIV/00023728:_____/12:#0004136
Result on the web
<a href="http://bloodjournal.hematologylibrary.org/content/120/14/2909" target="_blank" >http://bloodjournal.hematologylibrary.org/content/120/14/2909</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Inhibition of hedgehog signaling for the treatment of murine sclerodermatous chronic graft-versus-host disease
Original language description
Here, we examined the role of the hedgehog pathway in sclerodermatous cGvHD. Hedgehog signaling was activated in human and murine cGvHD. Treatment with LDE223, a highly selective small molecule antagonist of the hedgehog coreceptor Smoothened (Smo), abrogated the activation of hedgehog signaling and protected against experimental cGvHD.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FE - Other fields of internal medicine
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Blood
ISSN
0006-4971
e-ISSN
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Volume of the periodical
120
Issue of the periodical within the volume
14
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
2909-2917
UT code for WoS article
000311616900023
EID of the result in the Scopus database
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