Specific Cooperation Between Imp-alpha 2 and Imp-beta/Ketel in Spindle Assembly During Drosophila Early Nuclear Divisions

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A12788" target="_blank" >RIV/00216208:11110/12:12788 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1534/g3.111.001073" target="_blank" >http://dx.doi.org/10.1534/g3.111.001073</a>

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Specific Cooperation Between Imp-alpha 2 and Imp-beta/Ketel in Spindle Assembly During Drosophila Early Nuclear Divisions

Original language description

The multifunctional factors Imp-alpha and Imp-beta are involved in nuclear protein import, mitotic spindle dynamics, and nuclear membrane formation. Furthermore, each of the three members of the Imp-alpha family exerts distinct tasks during development.In Drosophila melanogaster, the imp-alpha 2 gene is critical during oogenesis for ring canal assembly; specific mutations, which allow oogenesis to proceed normally, were found to block early embryonic mitosis. Here, we show that imp-alpha 2 and imp-betagenetically interact during early embryonic development, and we characterize the pattern of defects affecting mitosis in embryos laid by heterozygous imp-alpha 2(D14) and imp-beta(KetRE34) females. Embryonic development is arrested in these embryos butis unaffected in combinations between imp-beta(KetRE34) and null mutations in imp-alpha 1 or imp-alpha 3. Furthermore, the imp-alpha 2(D14)/imp-beta(KetRE34) interaction could only be rescued by an imp-alpha 2 transgene, albeit not imp-al

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EA - Morphology and cytology

OECD FORD branch

—

Project

<a href="/en/project/GAP302%2F11%2F1640" target="_blank" >GAP302/11/1640: Morphological features and molecular determinants of apocrine secretion</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

G3-GENES GENOMES GENETICS

ISSN

2160-1836

e-ISSN

—

Volume of the periodical

2

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

14

Pages from-to

1-14

UT code for WoS article

—

EID of the result in the Scopus database

—