A Role of PI3K/Akt Signaling in Oocyte Maturation and Early Embryo Development
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F23%3A00574404" target="_blank" >RIV/67985904:_____/23:00574404 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/23:10471740
Result on the web
<a href="https://www.mdpi.com/2073-4409/12/14/1830" target="_blank" >https://www.mdpi.com/2073-4409/12/14/1830</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/cells12141830" target="_blank" >10.3390/cells12141830</a>
Alternative languages
Result language
angličtina
Original language name
A Role of PI3K/Akt Signaling in Oocyte Maturation and Early Embryo Development
Original language description
A serine/threonine-specific protein kinase B (PKB), also known as Akt, is a key factor in the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway that regulates cell survival, metabolism and proliferation. Akt phosphorylates many downstream specific substrates, which subsequently control the nuclear envelope breakdown (NEBD), centrosome maturation, spindle assembly, chromosome segregation, and cytokinesis. In vertebrates, Akt is also an important player during oogenesis and preimplantation development. In the signaling pathways regulating mRNA translation, Akt is involved in the control of mammalian target of rapamycin complex 1 (mTORC1) and thereby regulates the activity of a translational repressor, the eukaryotic initiation factor 4E (eIF4E) binding protein 1 (4E-BP1). In this review, we summarize the functions of Akt in mitosis, meiosis and early embryonic development. Additionally, the role of Akt in the regulation of mRNA translation is addressed with respect to the significance of this process during early development.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10605 - Developmental biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cells
ISSN
2073-4409
e-ISSN
2073-4409
Volume of the periodical
12
Issue of the periodical within the volume
14
Country of publishing house
CH - SWITZERLAND
Number of pages
16
Pages from-to
1830
UT code for WoS article
001038142100001
EID of the result in the Scopus database
2-s2.0-85165925962