Interactions of a Hydrophobically Modified Polycation with Zwitterionic Lipid Membranes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A12791" target="_blank" >RIV/00216208:11110/12:12791 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1021/la203748q" target="_blank" >http://dx.doi.org/10.1021/la203748q</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Interactions of a Hydrophobically Modified Polycation with Zwitterionic Lipid Membranes

Original language description

We have studied the impact of a hydrophobically modified strong polycation on the properties of a zwitterionic bilayer used as a model of the mammalian cellular membrane. Our results have shown that a new polycation, poly(allyl-N,Ndimethyl-N-hexylammonium chloride) can efficiently associate with and insert into the phosphocholine membrane without changing its lamellar structure. However, its binding promotes formation of hydrophilic pores in the membrane, thus increasing considerably its permeability.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

<a href="/en/project/LC535" target="_blank" >LC535: Chromosome dynamics and organization during the cell cycle in normal and pathologic conditions</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Langmuir

ISSN

0743-7463

e-ISSN

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Volume of the periodical

28

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

13

Pages from-to

676-688

UT code for WoS article

000298904900086

EID of the result in the Scopus database

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