Local treatment of hand-foot syndrome with uridine/thymidine: In vitro appraisal on a human keratinocyte cell line HaCaT

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A12943" target="_blank" >RIV/00216208:11110/12:12943 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/12:43906417 RIV/00216305:26620/12:PU103211 RIV/00064165:_____/12:12943
Result on the web
<a href="http://dx.doi.org/10.1100/2012/421325" target="_blank" >http://dx.doi.org/10.1100/2012/421325</a>
DOI - Digital Object Identifier
—

Result language
angličtina
Original language name
Local treatment of hand-foot syndrome with uridine/thymidine: In vitro appraisal on a human keratinocyte cell line HaCaT
Original language description
5-fluorouracil (5-FU) is one of the most commonly used antineoplastic drugs in the anticancer therapy. The hand-foot (HF) syndrome (palmar-plantar erythrodysesthesia) is an adverse effect frequently related to long-term i.v. administration of 5-FU or itsorally applicable prodrug capecitabine. Its severity can even lead to interruption of the otherwise effective anticancer therapy. Tentative practice in some clinics has shown that topical application of 10% uridine ointment is beneficial for calming down the HF syndrome. This study is focused on verifying the alleged protective activity of uridine in the in vitro model of cultured human keratinocyte cell line HaCaT. We also tested the protective effects of thymidine alone or uridine-thymidine combination. The cellular viability time progression was measured in order to evaluate the effect of protective agents by three different types of cytopathogenicity tests-NTCA test (non-destructive test of cellular activity), modified MTT test and
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
—

Project
<a href="/en/project/NS9786" target="_blank" >NS9786: Intracelular effects of uridin in the treatment of palmar-plantar erythrodyesthesia after long-term fluoropyrimidin administration- in vitro study</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)