Polymer conjugates of acridine-type anticancer drugs with pH-controlled activation

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A13240" target="_blank" >RIV/00216208:11110/12:13240 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/12:00377473 RIV/61389013:_____/12:00377473 RIV/00023001:_____/12:00056358
Result on the web
<a href="http://dx.doi.org/10.1016/j.bmc.2012.05.007" target="_blank" >http://dx.doi.org/10.1016/j.bmc.2012.05.007</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Polymer conjugates of acridine-type anticancer drugs with pH-controlled activation
Original language description
We synthesized five 9-anilinoacridine-type drugs and their conjugates with biocompatible water-soluble hydrazide polymer carrier. All of the synthesized acridine drugs retained their in vitro antiproliferative properties. Their polymer conjugates were sufficiently stable at pH 7.4 (model of pH in blood plasma) while releasing free drugs at pH 5.0 (model of pH in endosomes). After internalization of the conjugates, the free drugs were released and are visible in cell nuclei by fluorescence microscopy. Their intercalation ability was proven using a competitive ethidium bromide displacement assay.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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