Co-morbidity and self medication in schizophrenia: involvement of endogenous morphine signaling mechanisms
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A13383" target="_blank" >RIV/00216208:11110/12:13383 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/12:8774 RIV/00216208:11140/12:10133743 RIV/00064203:_____/12:8774
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Co-morbidity and self medication in schizophrenia: involvement of endogenous morphine signaling mechanisms
Original language description
For over 30 years, empirical studies have demonstrated expression of chemically authentic morphine by diverse animal tissues and organs systems. De novo biosynthesis of endogenous morphine by animal cells displays striking similarities to the multi-enzyme mediated biosynthetic pathway previously characterized in great biochemical and molecular detail in opium poppy (Papaver somniferum). The committed enzyme step within this pathway involves an asymmetric Pictet-Spengler condensation of dopamine (DA) and3,4 dihydroxyphenylacetaldehyde (DOPAL), the oxidation product of L-3,4-dihydroxyphenylalanine (L-DOPA), to form the essential intermediate precursor tetrahydropapaveroline (THP). We have hypothesized that endogenous morphine is synthesized within peripheral sites via conversion of THP in a regulated biosynthetic pathway, or conversely, THP may be directly transported into the CNS and converted to endogenous morphine within a similar biosynthetic pathway. The fundamental chemical relati
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FL - Psychiatry, sexology
OECD FORD branch
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Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Current drug targets
ISSN
1389-4501
e-ISSN
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Volume of the periodical
13
Issue of the periodical within the volume
11
Country of publishing house
AE - UNITED ARAB EMIRATES
Number of pages
4
Pages from-to
1454-1457
UT code for WoS article
000308355300011
EID of the result in the Scopus database
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