Effects of Combined Endothelin A Receptor and Renin-Angiotensin System Blockade on the Course of End-Organ Damage in 5/6 Nephrectomized Ren-2 Hypertensive Rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A13572" target="_blank" >RIV/00216208:11110/12:13572 - isvavai.cz</a>

Alternative codes found

RIV/67985823:_____/12:00390670 RIV/00023001:_____/12:00055970 RIV/00216208:11130/12:8110 RIV/00216208:11120/12:43898265 RIV/00064165:_____/12:13572

Result on the web

<a href="http://dx.doi.org/10.1159/000336823" target="_blank" >http://dx.doi.org/10.1159/000336823</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Effects of Combined Endothelin A Receptor and Renin-Angiotensin System Blockade on the Course of End-Organ Damage in 5/6 Nephrectomized Ren-2 Hypertensive Rats

Original language description

Our previous studies in rats with ablation nephrectomy have shown similar cardiorenal protective effects of renin-angiotensin system (RAS)-dependent treatment (combination of angiotensin-converting enzyme inhibitor and angiotensin II receptor blocker) and RAS-independent treatment (combination of alpha- and beta-adrenoreceptor antagonist and diuretics). Moreover, selective blockade of endothelin (ET) receptor type A (ETA) improved survival rate and attenuated hypertension and organ damage in Ren-2 transgenic rats. Therefore, we were interested in whether ETA receptor blockade could have additive effects to the classical blockade of the RAS. Transgenic rats underwent 5/6 renal ablation at the age of 2 months and were treated for 20 weeks with RAS blockers alone (angiotensin II receptor blocker - losartan, and angiotensin-converting enzyme inhibitor - trandolapril), ETA receptor blocker alone (atrasentan) or with the combination of RAS and ETA receptor blockade. RAS blockade normalized b

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

ED - Physiology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Kidney and Blood Pressure Research

ISSN

1420-4096

e-ISSN

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Volume of the periodical

35

Issue of the periodical within the volume

5

Country of publishing house

CH - SWITZERLAND

Number of pages

11

Pages from-to

382-392

UT code for WoS article

000305594600011

EID of the result in the Scopus database

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