Addition of ETA receptor blockade increases renoprotection provided by renin-angiotensin system blockade in 5/6 nephrectomized Ren-2 transgenic rats

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10293391" target="_blank" >RIV/00216208:11110/14:10293391 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/14:00439090 RIV/00216208:11120/14:43909401 RIV/00023001:_____/14:00058789 RIV/00064165:_____/14:10293391
Result on the web
<a href="http://dx.doi.org/10.1016/j.lfs.2013.12.018" target="_blank" >http://dx.doi.org/10.1016/j.lfs.2013.12.018</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.lfs.2013.12.018" target="_blank" >10.1016/j.lfs.2013.12.018</a>

Result language
angličtina
Original language name
Addition of ETA receptor blockade increases renoprotection provided by renin-angiotensin system blockade in 5/6 nephrectomized Ren-2 transgenic rats
Original language description
Aims: There is evidence that in addition to hypertension and hyperactivity of the renin-angiotensin system (RAS), enhanced intrarenal activity of endothelin (ET) system contributes to the pathophysiology and progression of chronic kidney disease (CKD). This prompted us to examine if this progression would be alleviated by addition of type A ET receptor (ETA) blockade to the standard blockade of RAS. Main methods: Ren-2 transgenic rats (TGR) after 5/6 renal ablation (5/6 NX) served as a model of CKD. ForRAS inhibition a combination of angiotensin-converting enzyme inhibitor (trandolapril, 6 mg/L drinking water) and angiotensin II type 1 receptor blocker (Iosartan, 100 mg/L drinking water) was used. Alternatively, ETA receptor blocker (atrasentan, 5 mg.kg(-1).day(-1) in drinking water) was added to the combined RAS blockade. The follow-up period was 44 weeks after 5/6 NX. and the rats' survival rate, systolic blood pressure (SOP), proteinuria and indices of renal glomerular damage were
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FE - Other fields of internal medicine
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
O - Projekt operacniho programu

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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