Novel Topical Photodynamic Therapy of Prostate Carcinoma Using Hydroxy-aluminum Phthalocyanine Entrapped in Liposomes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10138902" target="_blank" >RIV/00216208:11110/13:10138902 - isvavai.cz</a>

Alternative codes found

RIV/67985823:_____/13:00397555 RIV/28778758:_____/13:#0000051 RIV/00216208:11120/13:43907364 RIV/00064190:_____/13:#0000597

Result on the web

<a href="http://ar.iiarjournals.org/content/33/4/1563.full" target="_blank" >http://ar.iiarjournals.org/content/33/4/1563.full</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Novel Topical Photodynamic Therapy of Prostate Carcinoma Using Hydroxy-aluminum Phthalocyanine Entrapped in Liposomes

Original language description

Background: Clinically approved anticancer photodynamic therapy (PDT) is now heavily studied for various cancer diagnoses. We focused on the treatment efficacy of topical administration of hydroxy-aluminum phthalocyanine (AlOH-PC) entrapped in liposomesagainst in vivo models of prostate carcinomas. Materials and Methods: LNCaP and PC3 cells were subcutaneously injected into the right flank of athymic nude mice. Mice with grown tumours were used for in vivo efficacy studies. First by, we applied different doses of AlOH-PC to less aggressive LNCaP tumours to determine the efficient dose. In later studies, we focused on more aggressive prostate tumours (PC3) using doses of liposomal-AlOH-PC gel formulation. Topical application of photosensitizers was followed by PDT irradiation (600-700 nm, 635 nm peak). Tumour growth was measured three times a week. Results: Comparison of PDT of aggressive PC3 and less aggressive LNCaP prostate carcinomas showed that both tumour types are sensitive and

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Anticancer Research

ISSN

0250-7005

e-ISSN

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Volume of the periodical

33

Issue of the periodical within the volume

4

Country of publishing house

GR - GREECE

Number of pages

6

Pages from-to

1563-1568

UT code for WoS article

000317632200037

EID of the result in the Scopus database

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