Gadolinium- and Manganite-Based Contrast Agents with Fluorescent Probes for Both Magnetic Resonance and Fluorescence Imaging of Pancreatic Islets: A Comparative Study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10139596" target="_blank" >RIV/00216208:11110/13:10139596 - isvavai.cz</a>
Alternative codes found
RIV/68378271:_____/13:00425115 RIV/00216208:11310/13:10139596 RIV/00023001:_____/13:00058541
Result on the web
<a href="http://dx.doi.org/10.1002/cmdc.201200439" target="_blank" >http://dx.doi.org/10.1002/cmdc.201200439</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/cmdc.201200439" target="_blank" >10.1002/cmdc.201200439</a>
Alternative languages
Result language
angličtina
Original language name
Gadolinium- and Manganite-Based Contrast Agents with Fluorescent Probes for Both Magnetic Resonance and Fluorescence Imaging of Pancreatic Islets: A Comparative Study
Original language description
Three magnetic resonance (MR)/fluorescence imaging probes were tested for visualization, cellular distribution, and survival of labeled pancreatic islets invitro and following transplantation. As T1 contrast agents (CAs), gadolinium(III) complexes linkedto -cyclodextrin (Gd-F-CD) or bound to titanium dioxide (TiO2@RhdGd) were tested. As a T2 CA, perovskite manganite nanoparticles (LSMO@siF@si) were examined. Fluorescein or rhodamine was incorporated as a fluorescent marker in all probes. Islets labeledwith gadolinium(III) CAs were visible as hyperintense spots on MR invitro, but detection invivo was inconclusive. Islets labeled with LSMO@siF@si CA were clearly visible as hypointense spots or areas on MR scans invitro as well as invivo. All CAs were detected inside the islet cells by fluorescence. Although the vitality and function of the labeled islets was not impaired by any of the tested CAs, results indicate that LSMO@siF@si CA is a superior marker for islet labeling, as it provid
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CA - Inorganic chemistry
OECD FORD branch
—
Result continuities
Project
<a href="/en/project/GAP207%2F11%2F1437" target="_blank" >GAP207/11/1437: Novel classes of contrast agents for magnetic resonance imaging</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ChemMedChem
ISSN
1860-7179
e-ISSN
—
Volume of the periodical
8
Issue of the periodical within the volume
4
Country of publishing house
DE - GERMANY
Number of pages
8
Pages from-to
614-621
UT code for WoS article
000316811100010
EID of the result in the Scopus database
—