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Gadolinium- and Manganite-Based Contrast Agents with Fluorescent Probes for Both Magnetic Resonance and Fluorescence Imaging of Pancreatic Islets: A Comparative Study

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10139596" target="_blank" >RIV/00216208:11110/13:10139596 - isvavai.cz</a>

  • Alternative codes found

    RIV/68378271:_____/13:00425115 RIV/00216208:11310/13:10139596 RIV/00023001:_____/13:00058541

  • Result on the web

    <a href="http://dx.doi.org/10.1002/cmdc.201200439" target="_blank" >http://dx.doi.org/10.1002/cmdc.201200439</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1002/cmdc.201200439" target="_blank" >10.1002/cmdc.201200439</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Gadolinium- and Manganite-Based Contrast Agents with Fluorescent Probes for Both Magnetic Resonance and Fluorescence Imaging of Pancreatic Islets: A Comparative Study

  • Original language description

    Three magnetic resonance (MR)/fluorescence imaging probes were tested for visualization, cellular distribution, and survival of labeled pancreatic islets invitro and following transplantation. As T1 contrast agents (CAs), gadolinium(III) complexes linkedto -cyclodextrin (Gd-F-CD) or bound to titanium dioxide (TiO2@RhdGd) were tested. As a T2 CA, perovskite manganite nanoparticles (LSMO@siF@si) were examined. Fluorescein or rhodamine was incorporated as a fluorescent marker in all probes. Islets labeledwith gadolinium(III) CAs were visible as hyperintense spots on MR invitro, but detection invivo was inconclusive. Islets labeled with LSMO@siF@si CA were clearly visible as hypointense spots or areas on MR scans invitro as well as invivo. All CAs were detected inside the islet cells by fluorescence. Although the vitality and function of the labeled islets was not impaired by any of the tested CAs, results indicate that LSMO@siF@si CA is a superior marker for islet labeling, as it provid

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CA - Inorganic chemistry

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GAP207%2F11%2F1437" target="_blank" >GAP207/11/1437: Novel classes of contrast agents for magnetic resonance imaging</a><br>

  • Continuities

    S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2013

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    ChemMedChem

  • ISSN

    1860-7179

  • e-ISSN

  • Volume of the periodical

    8

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    8

  • Pages from-to

    614-621

  • UT code for WoS article

    000316811100010

  • EID of the result in the Scopus database