Changes in levels of matrix metalloproteinase-2 and-9, pregnancy-associated plasma protein-A in patients with various nephropathies

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10173656" target="_blank" >RIV/00216208:11110/13:10173656 - isvavai.cz</a>
Alternative codes found
RIV/68407700:21230/13:00206203 RIV/00064165:_____/13:10173656
Result on the web
<a href="http://dx.doi.org/10.5301/jn.5000136" target="_blank" >http://dx.doi.org/10.5301/jn.5000136</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5301/jn.5000136" target="_blank" >10.5301/jn.5000136</a>

Result language
angličtina
Original language name
Changes in levels of matrix metalloproteinase-2 and-9, pregnancy-associated plasma protein-A in patients with various nephropathies
Original language description
Background: Specific changes and imbalanced concentrations of matrix metalloproteinases (MMPs) and pregnancy-associated plasma protein-A (PAPP-A) may reflect the pathophysiology of various nephropathies (GN). We compared MMP-2, MMP-9 and PAPP-A levels inpatients with GN, with those found in healthy controls. Methods: We studied 45 controls and 128 patients with GN, defined by kidney biopsy: IgA nephropathy (IgAN, n=33), membranous glomerulonephritis (MN, n=23), minimal change nephrotic syndrome (MCNS,n=7), focal segmental glomerular sclerosis (FSGS, n=11), lupus nephritis (LN, n=22) and ANCA-associated glomerulonephritis (AAV, n=32). MMP-2 and MMP-9 levels were assessed using enzyme-linked immunosorbent assay; PAPP-A levels were determined with time-resolved amplified cryptate emission, and routine biochemical parameters were measured. Results: Compared with controls, IgAN patients exhibited a significant decrease in levels of MMP-2 contrasted with increased MMP-9 and unchanged PAPP-
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FE - Other fields of internal medicine
OECD FORD branch
—

Project
—
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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