ANCA-Associated Renal Vasculitis - An Update

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10173697" target="_blank" >RIV/00216208:11110/13:10173697 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/13:10173697

Result on the web

<a href="http://dx.doi.org/10.1159/000348634" target="_blank" >http://dx.doi.org/10.1159/000348634</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1159/000348634" target="_blank" >10.1159/000348634</a>

Result language

angličtina

Original language name

ANCA-Associated Renal Vasculitis - An Update

Original language description

ANCA-associated vasculitis (AAV) is a potentially life-threatening disease with frequent and often severe kidney involvement which may result in end-stage renal disease. Anti-PR3 and anti-MPO disease are genetically distinct diseases and may have a different pathogenesis. Recent discovery of new autoantibodies (anti-LAMP-2) and the role of complement activation in the pathogenesis of AAV could result in better monitoring of the activity of the disease and identification of new treatment targets. The outcome of patients with AAV has dramatically improved, but long-term mortality still remains relatively high partly due to effective but relatively toxic immunosuppressive treatment. Recent studies demonstrated that B-cell depletion with rituximab is comparable to cyclophosphamide as induction treatment in newly diagnosed AAV patients and better than cyclophosphamide in relapsing patients. Rituximab-based maintenance treatment is superior to standard treatment with azathioprine. The use of

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FE - Other fields of internal medicine

OECD FORD branch

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Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Contributions to Nephrology

ISSN

0302-5144

e-ISSN

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Volume of the periodical

181

Issue of the periodical within the volume

2013

Country of publishing house

CH - SWITZERLAND

Number of pages

13

Pages from-to

216-228

UT code for WoS article

000322846600023

EID of the result in the Scopus database

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