Moderator's view: Should all patients with ANCA-associated vasculitis be primarily treated with rituximab?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10297289" target="_blank" >RIV/00216208:11110/15:10297289 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/15:10297289

Result on the web

<a href="http://dx.doi.org/10.1093/ndt/gfv215" target="_blank" >http://dx.doi.org/10.1093/ndt/gfv215</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/ndt/gfv215" target="_blank" >10.1093/ndt/gfv215</a>

Result language

angličtina

Original language name

Moderator's view: Should all patients with ANCA-associated vasculitis be primarily treated with rituximab?

Original language description

Experience with rituximab in patients with new ANCA-associated vasculitis (AAV) is still very limited, especially in patients with severe (organ- or life-threatening) AAV. Rituximab may be more effective in anti-PR3 AAV, but potentially less effective insome granulomatous manifestations of AAV. We do not know what the response is to rituximab on the tissue level. Rituximab induction needs to be followed by maintenance treatment, and potentially very long rituximab maintenance may result in higher riskof rituximab-related complications (e.g. decrease in IgG levels). Long-term experience with rituximab in AAV is insufficient. Treatment with rituximab is more expensive than the standard treatment with cyclophosphamide and corticosteroids and seems to becost-effective only in patients primarily treated with cyclophosphamide. Rituximab can be used in some newly diagnosed patients with AAV (e.g. women with child-bearing potential, or patients with active vasculitis and severe infection),

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FE - Other fields of internal medicine

OECD FORD branch

—

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nephrology Dialysis Transplantation

ISSN

0931-0509

e-ISSN

—

Volume of the periodical

30

Issue of the periodical within the volume

7

Country of publishing house

GB - UNITED KINGDOM

Number of pages

3

Pages from-to

1088-1090

UT code for WoS article

000359780300009

EID of the result in the Scopus database

2-s2.0-84936804172