Comparative Analysis of IL-8 and CXCL-1 Production by Normal and Cancer Stromal Fibroblasts

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10174094" target="_blank" >RIV/00216208:11110/13:10174094 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/13:10174094

Result on the web

<a href="http://fb.cuni.cz/file/5691/FB2013A0018.pdf" target="_blank" >http://fb.cuni.cz/file/5691/FB2013A0018.pdf</a>

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Comparative Analysis of IL-8 and CXCL-1 Production by Normal and Cancer Stromal Fibroblasts

Original language description

It has been shown that fibroblasts within the stroma of malignant tumours can affect the tumour's biological character, influencing such properties as local aggressiveness and metastasis potential. This influence is asserted via paracrine secretion of multiple cell factors, including chemokines. This study demonstrates that both normal keratinocytes and cancer cells can stimulate the secretion of chemokines IL-8 and CXCL-1 from normal dermal fibroblasts and stromal fibroblasts from squamous cell carcinoma. The effect of epithelia on normal fibroblasts leads to a transient secretory change, in contrast to stromal fibroblasts which generate a more prolonged one. This observation demonstrates that stimulated expression of both IL-8 and CXCL-1 is not specific to cancer, supporting the hypothesis that similar mechanisms exist between wound healing and oncogenesis. It also shows that stromal fibroblasts isolated from a tumour have significantly different features from normal fibroblasts.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

—

Project

<a href="/en/project/NT13488" target="_blank" >NT13488: Genomic analysis of tumor-associated fibroblasts in head and neck carcinoma: The basis for new generation of biologic anti-tumor therapy</a><br>

Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Folia Biologica

ISSN

0015-5500

e-ISSN

—

Volume of the periodical

59

Issue of the periodical within the volume

3

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

4

Pages from-to

134-137

UT code for WoS article

000322419900006

EID of the result in the Scopus database

—