Cultivation-dependent plasticity of melanoma phenotype

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10188864" target="_blank" >RIV/00216208:11110/13:10188864 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/13:10188864 RIV/00216224:14110/13:00069858

Result on the web

<a href="http://dx.doi.org/10.1007/s13277-013-0905-x" target="_blank" >http://dx.doi.org/10.1007/s13277-013-0905-x</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s13277-013-0905-x" target="_blank" >10.1007/s13277-013-0905-x</a>

Result language

angličtina

Original language name

Cultivation-dependent plasticity of melanoma phenotype

Original language description

Malignant melanoma is a highly aggressive tumor with increasing incidence and high mortality. The importance of immunohistochemistry in diagnosis of the primary tumor and in early identification of metastases in lymphatic nodes is enormous; however melanoma phenotype is frequently variable and thus several markers must be employed simultaneously. The purposes of this study are to describe changes of phenotype of malignant melanoma in vitro and in vivo and to investigate whether changes of environmentalfactors mimicking natural conditions affect the phenotype of melanoma cells and can revert the typical in vitro loss of diagnostic markers. The influence of microenvironment was studied by means of immunocytochemistry on co-cultures of melanoma cells with melanoma-associated fibroblast and/or in conditioned media. The markers typical for melanoma (HMB45, Melan-A, Tyrosinase) were lost in malignant cells isolated from malignant effusion; however, tumor metastases shared identical phenotyp

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

<a href="/en/project/GAP304%2F12%2F1333" target="_blank" >GAP304/12/1333: Intercellular interactions in malignant melanoma - experimental study</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Tumor Biology

ISSN

1010-4283

e-ISSN

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Volume of the periodical

34

Issue of the periodical within the volume

6

Country of publishing house

DE - GERMANY

Number of pages

11

Pages from-to

3345-3355

UT code for WoS article

000328292100010

EID of the result in the Scopus database

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