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ImmunoChip Study Implicates Antigen Presentation to T Cells in Narcolepsy

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10189358" target="_blank" >RIV/00216208:11110/13:10189358 - isvavai.cz</a>

  • Alternative codes found

    RIV/00064165:_____/13:10189358

  • Result on the web

    <a href="http://dx.doi.org/10.1371/journal.pgen.1003270" target="_blank" >http://dx.doi.org/10.1371/journal.pgen.1003270</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1371/journal.pgen.1003270" target="_blank" >10.1371/journal.pgen.1003270</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    ImmunoChip Study Implicates Antigen Presentation to T Cells in Narcolepsy

  • Original language description

    Recent advances in the identification of susceptibility genes and environmental exposures provide broad support for a post-infectious autoimmune basis for narcolepsy/hypocretin (orexin) deficiency. We genotyped loci associated with other autoimmune and inflammatory diseases in 1,886 individuals with hypocretin-deficient narcolepsy and 10,421 controls, all of European ancestry, using a custom genotyping array (ImmunoChip). Three loci located outside the Human Leukocyte Antigen (HLA) region on chromosome6 were significantly associated with disease risk. In addition to a strong signal in the T cell receptor alpha (TRA@), variants in two additional narcolepsy loci, Cathepsin H (CTSH) and Tumor necrosis factor (ligand) superfamily member 4 (TNFSF4, also called OX40L), attained genome-wide significance. These findings underline the importance of antigen presentation by HLA Class II to T cells in the pathophysiology of this autoimmune disease.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FH - Neurology, neuro-surgery, nuero-sciences

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2013

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    PLoS Genetics [online]

  • ISSN

    1553-7404

  • e-ISSN

  • Volume of the periodical

    9

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    7

  • Pages from-to

  • UT code for WoS article

    000315638300028

  • EID of the result in the Scopus database