Anti-Tribbles Homo log 2 (TRIB2) Autoantibodies in Narcolepsy are Associated with Recent Onset of Cataplexy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F10%3A6753" target="_blank" >RIV/00216208:11110/10:6753 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/10:6753

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Anti-Tribbles Homo log 2 (TRIB2) Autoantibodies in Narcolepsy are Associated with Recent Onset of Cataplexy

Original language description

Anti-TRIB2 autoantibodies are prevalent in narcolepsy, the highest positivity was found in HLA-DQB1-0602 positive cases with cataplexy. Their presence is associated with duration of cataplexy, and therefore, depends on duration of illness. Anti- TRIB2 autoantibodies are strongly associated with narcolepsy close to cataplexy onset (less to 2.3 years). They was rarely found in cases without cataplexy or with distant onset. The paper brings further support for autoimmune aetiology of the disease, anti-TRIB2 autoantibodies destroy selectively hypothalamic neurons producing hypocretin/orexin.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Sleep

ISSN

0161-8105

e-ISSN

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Volume of the periodical

33

Issue of the periodical within the volume

7

Country of publishing house

US - UNITED STATES

Number of pages

6

Pages from-to

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UT code for WoS article

000279365600006

EID of the result in the Scopus database

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