Prolonged overdose of all-trans retinoic acid enhances bone sensitivity in castrated mice

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10189375" target="_blank" >RIV/00216208:11110/13:10189375 - isvavai.cz</a>
Alternative codes found
RIV/61383082:_____/13:0022 RIV/00064165:_____/13:10189375
Result on the web
<a href="http://dx.doi.org/10.1016/j.nut.2013.03.011" target="_blank" >http://dx.doi.org/10.1016/j.nut.2013.03.011</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.nut.2013.03.011" target="_blank" >10.1016/j.nut.2013.03.011</a>

Result language
angličtina
Original language name
Prolonged overdose of all-trans retinoic acid enhances bone sensitivity in castrated mice
Original language description
Objectives: Intake of multivitamin preparations is very common in developed countries. However, excessive intake of vitamin A was associated with increased bone fragility. The aim of this study was to determine if chronic administration of the active metabolite of vitamin A all-trans-retinoic acid (ATRA) in slight excess is associated with changes of bone turnover and density in intact and castrated mice. Method: Three mo old male mice (C57B1/6) intact and castrated were injected intraperitonealy with 10 mg/kg/d of the ATRA or vehicle (control) once daily for 3 wk. The bone density, ash weights, calcium, and phosphorus content of the femur were measured. Plasma tartrate-resistant acid phosphatase (Tr-ACP) and serum bone alkaline phosphatase (B-ALP) were determined. Results: ATRA decreased bone density in both groups; however, this effect was more pronounced in castrated animals (1.487 +/- 0.04 to 1,360 +/- 0.05 g/cm(3)) than in intact mice (1.570 +/- 0.03 to 1.510 +/- 0.03 g/cm(3)). Bo
Czech name
—
Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
—

Project
<a href="/en/project/NT11335" target="_blank" >NT11335: Bone metabolism in patients with type 2 diabetes mellitus: role of the receptor for advanced glycation end products (RAGE) and its gene polymorphism</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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