Long-Term Results of Enriched Environment and Erythropoietin After Hypobaric Hypoxia in Rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10189581" target="_blank" >RIV/00216208:11110/13:10189581 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/13:10189581

Result on the web

<a href="http://www.biomed.cas.cz/physiolres/pdf/62/62_463.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/62/62_463.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Long-Term Results of Enriched Environment and Erythropoietin After Hypobaric Hypoxia in Rats

Original language description

After global cerebral hypoxia, many patients are severely disabled even after intensive neurorehabilitation. Secondary mechanisms of brain injury as a result of biochemical and physiological events occur within a period of hours to months, and provide awindow of opportunity for therapeutic intervention. Erythropoietin (EPO) has been shown to be neuroprotective in the brain subjected to a variety of injuries. Fifty-nine 3-month-old male Wistar rats were randomly distributed to experimental groups with respect to the housing (enriched environment - EE, standard housing - SH), to hypoxia exposure, and to EPO treatment. An acute mountain sickness model was used as a hypobaric hypoxia simulating an altitude of 8000 m. One half of the animals received erythropoietin injections, while the others were injected saline. Spatial memory was tested in a Morris water maze (MWM). The escape latency and the path length were measured. Better spatial learning in MWM was only seen in the group that rece

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

ED - Physiology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

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Volume of the periodical

62

Issue of the periodical within the volume

4

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

8

Pages from-to

463-470

UT code for WoS article

000323510500014

EID of the result in the Scopus database

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